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Defence potions are made by mixing ranarr weed and white berries in a vial of water, requiring a Herblore level of 30 and giving 75 Herblore experience. It can be bought at the Warrior Guild Potion Shop for 114 coins. Defence potions temporarily raise your Defence level by 10% + 3.

During the Jekyll and Hyde random event, if you give Dr. Jekyll a toadflax herb, he will give out a defence potion.

As ranarr weeds are also used in the much more popular prayer potion, many players believe that making defence potions is a waste of ranarr weeds.

Level Boost
1-9 3
10-19 4
20-29 5
30-39 6
40-49 7
50-59 8
60-69 9
70-79 10
80-89 11
90-99 12

Price per dose

Item Price per dose
Defence potion(1) Defence potion(1) 214
Defence potion(2) Defence potion(2) 159
Defence potion(3) Defence potion(3) 130
Defence potion(4) Defence potion(4) 148

Dropping monsters

Defence potion(3)

Monster Combat level Quantity Rarity
Abyssal demon 124 1 3; Uncommon
Kalphite Guardian 141 1 3; Uncommon
Greater abyssal demon 342 1 3; Uncommon
Black demon 172; 178; 184 1 4; Rare

Defence potion(4)

Monster Combat level Quantity Rarity
Possessed Priest 91 1 6; Random
Young impling N/A 1 4; Rare