|391,600 per hour|
450 x Water orb (634,500)
Water orbs are worth 1,410 coins, and they are created by casting Charge Water Orb on unpowered orbs at the Water Obelisk. With a water staff equipped, this requires three cosmic runes per cast (or 399 coins). Using Falador teleports for banking, players can charge 26 orbs per trip (one inventory slot is needed for the cosmic runes), resulting in a profit of 22,652 coins per trip.
The Water Obelisk is located in the Taverley Dungeon. Using the map on the right as a guide through the dungeon, the round trip to the obelisk, counting banking, takes approximately 185 seconds using the 80 Agility shortcut, 205 seconds using the 70 Agility shortcut, or 325 seconds without any shortcuts.
Bear in mind that running through the Taverley Dungeon places you in combat range of aggressive black demons, hellhounds, poison spiders, and black dragons. A good Defence level is recommended. Also, having some Antipoison in your bank helps due to possible poisoning from the poisonous spiders.
Assuming the unpowered orbs and cosmic runes are purchased, you can make around 505 water orbs an hour using the level 80 Agility shortcut (439,615 coins), 450 water orbs using the level 70 Agility shortcut (391,626 coins), and 280 water orbs using no shortcuts (243,802 coins).
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